The effect of clonidine on heart rate variability analysis in patients undergoing key-hole surgery to remove gallbladder
A prospective study to validate the effect of clonidine on Analgesia Nociceptive Index in patients undergoing laparoscopic cholecystectomy
fremantle Hospital
44 participants
Sep 17, 2012
Interventional
Conditions
Summary
Clonidine has been effectively used as a non-opioid (morphine-like) pain killer and sedative in a variety of clinical settings for many years. The Analgesia Nociceptive Index (ANI) monitor is a novel anaesthetic monitor that has been developed for use with opioid based pain killers. It works by assessing (primarily) heart rate variability to generate a score which gives an indication of nociceptive (painful) inputs. This study aims to examine the effects of clonidine on the ANI under general anaesthesia for laparoscopic cholecystectomy, as part of the pain relieving strategy
Eligibility
Inclusion Criteria1
- Laparoscopic cholecystectomy
Exclusion Criteria7
- unable to consent
- below 18 years old
- Established arrhythmias
- Allergy/sensitivity to clonidine
- diabetes mellitus and autonomic neuropathy
- sepsis/ emodynamic instability
- chronic pain
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Interventions
Patients will receive a standardised protocol for induction of anaesthesia with fentanyl, propofol and rocuronium. . A standard IV paracetamol 1g and IV Parecoxib 40mg (if no contraindication) are also given. Analgesia Nociception Index (ANI) will be recorded at every 5 minute intervals. IV Clonidine 1mcg/kg will be given 5 mins following pneumoperitoneum. Any further dose of fentanyl given will be recorded
Locations(1)
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ACTRN12612001075875