RecruitingACTRN12612001253897

Porvoo Sarcopenia & Nutrition Trial

In older people with sarcopenia, does protein supplementation, compared to isocaloric placebo or no supplementation, maintain or improve physical performance


Sponsor

University of Helsinki

Enrollment

250 participants

Start Date

Apr 11, 2012

Study Type

Interventional

Conditions

Summary

Age related muscle loss i.e. sarcopenia is a common health problem among older people and physical exercise and dietary protein has been emphasized in prevention and treatment of sarcopenia. Rigorous trials investigating effects of protein supplementation on physical performance in sarcopenic populations are still scarce. The aim of this study is to investigate the effects of protein supplementation along with simple home-based exercises on physical performance among home-dwelling sarcopenic older people. During 2012 the entire 75+ population (N = 3275) living in Porvoo, Finland will be approached by a postal questionnaire and persons at risk of sarcopenia are further screened for this randomized controlled trial.


Eligibility

Sex: Both males and femalesMin Age: 75 Yearss

Plain Language Summary

Simplified for easier understanding

This study is testing whether protein supplements combined with simple home exercises can help older adults maintain or build muscle strength. Age-related muscle loss — called sarcopenia — is a common and serious health problem in older people that increases the risk of falls and disability. Researchers in Finland will screen the entire population aged 75 and older in Porvoo to find people who may be losing muscle, then invite them to join the trial. You may be eligible if: - You are 75 years or older and live at home in Porvoo, Finland - You have low grip strength (men under 30 kg, women under 20 kg) or walk slowly (under 0.80 m/s) - You have reduced muscle mass measured by a special body composition test You may NOT be eligible if: - You do not live independently at home - You cannot walk indoors without full assistance (canes and walkers are allowed) - Your kidney function is significantly impaired (blood creatinine above 150 µmol/L) - You have a terminal illness with less than 6 months to live - You have a cardiac pacemaker - You have had both knees replaced Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Arm 1. standard treatment and no supplementation for 12 months Arm 2. standard treatment and milk protein supplementation of 20 grams (50% whey) twice a day for 12 months. The protein supplementati

Arm 1. standard treatment and no supplementation for 12 months Arm 2. standard treatment and milk protein supplementation of 20 grams (50% whey) twice a day for 12 months. The protein supplementation will be given in a form of 250 ml x 2 strawberry flavoured beverage and it contains 70 kcal/100ml of energy. Arm 3. standard treatment and isocaloric placebo supplementation twice a day for 12 months. The isocaloric placebo supplementation will be given in a form of 250 ml x 2 strawberry flavoured beverage and it contains 1 g/100ml milk proteins (20% whey) and 70 kcal/100ml of energy. Standard treatment will include: a) instructions to perform twice a day 10-30 min home based unsupervised simple exercises (chair rise, steps, etc.), b) instructions to eat proteins on every meal from different protein sources of regular foods, and c) instructions to use vitamin D3 supplementation with a dose of 20 ug/d. The compliance to all treatments is up to the participants themselves and the compliance is followed by daily written patient diaries that are collected every three months.


Locations(1)

Finland

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ACTRN12612001253897