Evaluation of brain perfusion by Tc-99m ECD SPECT/CT, plasma biomarker and cognition function in sleep obstructive apnea patients before and after treatment
Evaluation of brain perfusion by Tc-99m ECD SPECT/CT, plasma biomarker and cognition function in sleep obstructive apnea patients before and after CPAP or surgery treatment.
Show Chwan Memorial Hospital
70 participants
May 13, 2013
Interventional
Conditions
Summary
The aim of the study is to evaluate brain perfusion on Tc-99m ECD SPECT/CT, cognition function test and questionnaires in OSA patients before and after treatment.
Eligibility
Inclusion Criteria2
- moderate and severe degree obstructive sleep apnea patients
- age: 20~60 years old
Exclusion Criteria1
- Patients with symptoms of present of other sleep disorder, history of receiving medical intervention for sleep-related breathing disorder, cognition deterioration, hypertension, cancer, use of psychoactive medication, history of head injury with conscious loss and structural brain abnormalities
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Interventions
There are two interventions (CPAP and surgery). CPAP: Brad of ResMed-- S8 autoset Spirit in automatic positive airway pressure model. The participants put on the facial mask when sleeping, open the power of machine and the machine will start to work and automatically give the postitive pressure. Duration: 4 to 8 hours a day for 3 months Surgery: Uvulopalatopharyngoplasty, occur once. Approximate duration of uvulopalatopharyngoplasty: 1 hour All participants undergo only one intervention. Either CPAP or surgery treatment will be chosen by each participant.
Locations(1)
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ACTRN12612001311842