the effect of ondansetron on hypotension due to spinal anesthesia for caesarean section.
spinal-induced hypotension reduction with ondansetron in parturients undergoing caesarean section: A double-blind randomised, controlled study.
Tunisian Military Hospital
80 participants
Feb 5, 2013
Interventional
Conditions
Summary
spinal-induced hypotension results primarily from decreased vascular resistance secondary to a relative parasympathetic dominance, increased baroreceptor activity, or induction of the Bezold Jarisch Reflex (BJR). several animal studies suggest that 5-HT (serotonin) may be an important factor associated inducing the BJR. We hypothesized that spinal-induced hypotension and bradycardia could be minimized with the use of intravenous ondansetron, a 5-HT3 receptor antagonist, in obstetric patients undergoing caesarean section.
Eligibility
Inclusion Criteria1
- parturients ,who were ASA physical status I, undergoing an elective caesarean section
Exclusion Criteria4
- Parturients with contraindications to subarachnoid block
- (patient refusal, unstable haemodynamics, coagulation
- abnormality), history of hypersensitivity to ondansetron or local anaesthetic agents, hypertensive disorders of
- pregnancy, cardiovascular insufficiency and parturients receiving selective serotonin reuptake inhibitors
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Interventions
4 mg ondansetron (4 milliliters) given intravenously, 5 minutes before spinal anesthesia (using 10 mg hyperbaric bupivacaine 0.5% plus 2.5 microgramm sufentanil)
Locations(1)
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ACTRN12613000036718