Study of the pharmacokinetics [the way the body handles drug] of paracetamol and phenylephrine in healthy adults
Randomised single dose two arm cross-over open label study to determine the bioavailability of paracetamol and phenylephrine tablets relative to concomitant administration of Sudafed Nasal Decongestant and Panadol after an oral administration of two tablets to healthy adults under fasting conditions
AFT Pharma
30 participants
Mar 3, 2013
Interventional
Conditions
Summary
To measure the pharmacokinetics [how the body treats drugs] of phenylephrine in humans since this is still not well understood
Eligibility
Inclusion Criteria1
- Healthy volunteers
Exclusion Criteria1
- pregnancy, nursing, drug abuse, smoking > 10 cigarettes per day, excess alcohol intake, Rx drugs within 14 days of the study, participating in another trial within 80 days, clinically significant abnormal lab tests
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Interventions
Drug and dose: Paracetamol 1000mg and Phenylephrine 10mg Dose frequency: single dose Duration Administration: single dose Mode Administration: Oral tablet Wash-out between treatments = 7 days
Locations(1)
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ACTRN12613000197730