Reducing impulsivity in repeat violent offenders using a selective serotonin reuptake inhibitor (sertraline)

Research shows a strong link between poor impulse control and violent behaviour. People with impulsivity have reduced activity in the brain's serotonin pathways — the chemical system that helps regulate mood and self-control. This trial is testing whether sertraline, a commonly prescribed antidepressant from the SSRI class, can improve impulse control in repeat violent male offenders and reduce the likelihood of future violent offending. It uses a rigorous double-blind design, meaning neither participants nor researchers know who receives the real drug. You may be eligible if: - You are a male 18 years of age or older (up to 70) - You have been convicted of 2 or more violent offences - You score 70 or above on the Barratt Impulsiveness Scale - You are medically fit and able to provide informed consent You may NOT be eligible if: - You are currently taking an SSRI, SNRI, or tricyclic antidepressant - You have had an adverse reaction to SSRIs before - You are taking antipsychotic medication - You have a severe mental illness or are considered at high risk of suicide - You are expecting to receive a custodial prison sentence - You have significant kidney or liver problems - You have been convicted of murder or child sexual assault - You are about to be deported or move to a remote area Talk to your doctor about whether this trial might be right for you.