Dexmeditomedine for mitral valve replacement
dexmeditomedine for heart rate control during mitral valve replacement for mitral stenosis a randomised controlled double blind study
south valley university -Qena university hospital
70 participants
Nov 5, 2011
Interventional
Conditions
Summary
testing the efficacy and safety of dexmeditomedine in controlling heart rate in patients with tight mitral stenosis subjected to mitral valve replacement during the prebypass period
Eligibility
Inclusion Criteria1
- patients ASAI&II with tight ( less than one centimeter ) mitral stenosis aged 18-60 years of age scheduled for mitral valve replacement
Exclusion Criteria1
- age above or below 18-60 years , mitral valve area more than one centimeter, renal or hepatic dysfunction , cardiac medications that affect heart rate
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Interventions
70 patients scheduled for mitral valve replacement divided equally into two groups were studied in this randomized controlled double blind study ; Group D : received (after induction of anesthesia) dexmeditomedine 1ug/kg bolus dose over 10 minutes followed by an infusion of 0.5 ug/kg/h till the start of cardiopulmonary bypass. Group F: received saline bolus ( after induction of anesthesia ) and infusion of saline till the start of cardiopulmonary bypass instead of dexmeditomedine .Anesthetic management for both groups was the same.
Locations(1)
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ACTRN12613000495729