A pilot study of corticosteroid and antihistamine premedication to prevent hypersensitivity reactions in patients receiving second (or subsequent) line treatment with Carboplatin for treatment of gynaecological malignancy

The study is evaluating whether premedication can prevent or delay the onset of carboplatin hypersensitivity reactions in women win gynaecological malignancy. Who is it for? You may be eligible to join this study if you are aged 18 years or above and have been diagnosed with a gynaecological malignancy, for which you will be commencing a carboplatin containing chemotherapy regime. Eligible patients will have already undergone at least one prior line of carboplatin containing therapy. Trial details All participants in this study will be given premedication with Dexamethasone, Loratadine and Ranitidine the night before chemotherapy, the morning of chemotherapy and about 30 minutes prior to chemotherapy. These will be administered orally (by mouth) the night before and the morning of chemotherapy, and intravenously (directly into the vein) about 30 minutes prior to chemotherapy. All participants will be asked to complete a symptom diary, and will be clinically assessed in order to evaluate whether the study premedication can prevent or delay the onset of hypersensitivity reactions following chemotherapy with carboplatin. If it does (compared to a control group who receive their care in the past), then a subsequent larger randomised trial will be developed.