The Effect of Intranasal Dexmedetomidine Premedication on the Minimum Alveolar Concentration of Sevoflurane for tracheal intubation in children
Yusheng Yao
90 participants
Jul 11, 2013
Interventional
Conditions
Summary
Sevoflurane is generally employed for inhalation induction of anesthesia and tracheal intubation in children without muscle relaxant.Clinical trials have demonstrated that intranasal dexmedetomidine is an effective sedative for premedication in children.The ability of dexmedetomidine to reduce both the inhalation anesthetic and opioid analgesic requirements has been confirmed previously. However, to date, the effects of dexmedetomidine premedication on the minimum alveolar concentration of sevoflurane for tracheal intubation (MACTI) in pediatric patients is still undetermined.
Eligibility
Inclusion Criteria1
- American Society of Anesthesiologists physical status I-II children scheduled to undergo general anesthesia for elective minor surgery
Exclusion Criteria1
- Patients with airway malformation, clinical evidence of a difficult airway, any sign of upper respiratory infection, or asthma were excluded. Patients taking medication known to affect anesthetic requirements were also excluded.
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Interventions
GroupD1 received 1mcg/Kg intranasal dexmedetomidine premedication 60 min before general anaesthesia; GroupD2 received 2mcg/Kg intranasal dexmedetomidine premedication 60 min before general anaesthesia.Before tracheal intubation was attempted, the end-tidal concentration of sevoflurane was kept constant at the predetermined value at least 15 min, Once the response to tracheal intubation was recorded, further administration of anesthetic and analgesic agents was at the attending anesthesiologist’s discretion.
Locations(1)
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ACTRN12613000679785