McCusker KARVIAH: Curcumin in Alzheimer's disease prevention

Exclusion Criteria14

• Diagnosis of dementia based on the revised criteria from NIA/AA
• Montreal Cognitive Assessment (MoCA) score less than or equal to 17
• Significant functional impairments/behavioural problems as indicated by the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) and the 36-Item Short Form Health Survey (SF-36)
• Presence of acute functional psychiatric disorder including; lifetime history of schizophrenia or bipolar disorder
• Prior medical history of stroke
• History of alcohol or drug abuse / dependence within 2 years of screening
• Depression, as indicated on the DASS
• Use of Warfarin, within 4 weeks of screening
• Current or previous bile duct obstruction, gallstones, and gastrointestinal disorder
• Contraindication to MRI, including, but not limited to those with a pacemaker, presence of metallic fragments near the eyes or spinal cord, or cochlear implant
• History of closed angle glaucoma, or related conditions, contraindicated for retinal scanning
• Uncontrolled hypertension (systolic BP > 170 or diastolic BP > 100)
• Any significant systemic illness or unstable medical condition that could lead to difficulty complying with the protocol including: history of myocardial infarction in the past year or unstable or severe cardiovascular disease including angina or congestive heart disease, chronic renal failure, chronic hepatic disease, severe pulmonary disease
• Clinically significant and unstable gastrointestinal disorder such as ulcer disease or a history of active or occult gastrointestinal bleeding within two years.