Patient-controlled analgesia with methoxyflurane (Penthrox inhaler) versus conventional endoscopist-provided sedation for colonoscopy: a randomized multi-centre trial

This study is comparing two ways of managing pain and discomfort during a colonoscopy procedure. One method uses a hand-held inhaler with a medication called methoxyflurane (Penthrox), which the patient controls themselves by breathing through the device. The other method uses the conventional approach where the doctor gives intravenous sedation (midazolam and fentanyl) through a drip. Researchers want to find out if patient-controlled inhalation is as effective and safe as doctor-administered sedation. You may be eligible if: - You are between 18 and 75 years old - You are scheduled for a colonoscopy - You are able to give informed consent - You can understand how to use the Penthrox inhaler You may NOT be eligible if: - You drink heavily (more than 40 g/day for men, 20 g/day for women) or use narcotics regularly - You have significant heart disease or chronic lung disease - You weigh less than 45 kg - You have diabetes, kidney problems, or a history of gastrointestinal surgery - You have had a previous head injury - You or a family member has a history of malignant hyperthermia - You do not read English Talk to your doctor about whether this trial might be right for you.