Palonosetron and aprepitant for prevention of postoperative nausea and vomiting in patient undergoing laparoscopic gynecology surgery.
In patients undergoing laparoscopic gynecologic surgery, which is more effective for the prevention of postoperative nausea and vomiting between palonosetron and aprepitant.
Chung-ang university
100 participants
Oct 1, 2011
Interventional
Conditions
Summary
Postoperative nausea and vomiting (PONV) frequently develops in patients undergoing laparoscopic gynecologic surgery, The present study was undertaken to compare the effects of palanosetron and aprepitant on PONV in patients following laparoscopic gynecologic surgery. Patients were randomly assigned to one of two groups to receive antiemetics as follows: palanosetron 0.075 mg or aprepitant 40 mg. PONV, postoperative pain intensity, rescue antiemetics requirement, and side effects were assessed at 0, 2, 6, 24, 48 hr postoperatively.
Eligibility
Inclusion Criteria1
- patients undergoing laparoscopic gynecologic surgery
Exclusion Criteria1
- Pregnant women, 60 years of age or older and under 20 years old, weight 45kg or less, or more than 100kg, more than American society of Anesthesiologist grade three , history of previous postoperative nausea and vomiting, history of motion sickness, smokers, patient of serious cardiovascular system, kidney, liver, and hematological abnormalities.
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Interventions
before 1 hour to induction of anesthesia aprepitant 40 mg was given to patients by oral
Locations(1)
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ACTRN12613000902796