Comparative study between cabergoline and intravenous calcium in the prevention of ovarian hyper stimulation in women with polycystic ovarian disease undergoing Intracytoplasmic sperm injection (ICSI ).

This study compares two treatments for women with polycystic ovarian syndrome (PCOS) who are at risk of ovarian hyperstimulation syndrome (OHSS) during IVF (specifically a procedure called ICSI). OHSS is a painful and potentially serious side effect of fertility treatment where the ovaries become swollen. The study compares whether a medication called cabergoline (taken by mouth) or calcium given through a vein works better at preventing this complication, without affecting the chances of pregnancy. You may be eligible if: - You are a woman between 20 and 40 years old - You have polycystic ovarian syndrome (PCOS) and are having difficulty conceiving (subfertile) - Your FSH (a hormone) is within the normal range (1–12 IU/L) - You have at least 15 follicles larger than 10 mm at the time of the HCG trigger injection You may NOT be eligible if: - You require a technique called "coasting" because your OHSS risk is very high - Your cycle needs to be cancelled - Your partner has very severe male infertility requiring surgical sperm retrieval Talk to your doctor about whether this trial might be right for you.