Not Yet RecruitingPhase 1ACTRN12613001316796

Endometrial preparation for cryo embryo transfer: effect of Gonadotropin Releasing Hormone Agonists (GnRHa) coupled with oestrogen and progesterone on hormonal profile and pregnancy rate

The effect of endometrial preparation by pretreatment with Gonadotrophin-releasing hormone agonist (GnRha), oestrogen and progesterone, compared to endometrial preparation by oestrogen and progesterone only, on clinical pregnancy rate in infertile couples undergoing cryo embryo transfer as treatment for infertility

Sponsor

Elshatby University Maternity Hospital Department of Obstetrics and Gynecology

Enrollment

140 participants

Start Date

Dec 1, 2013

Study Type

Interventional

Conditions

Infertility

Summary

The aim of the work is compare artificial endometrial preparation by oestrogen and progesterone versus pretreatment with Gonadotrophin-releasing hormone agonist (GnRha), oestrogen and progesterone for cryo embryo transfer according to clinical pregnancy rate.

Eligibility

Sex: FemalesMin Age: 18 YearssMax Age: 35 Yearss

Inclusion Criteria5

Age: 35 years old or less.
Infertility: primary or secondary
Embryos: were frozen on day five.
Cryopreservation: closed method vitrification
Laser assisted hatching prior to embryo transfer.

Exclusion Criteria2

Age above 35 years old.
Abnormal uterine factor diagnosed by Vaginal sonography, Hysteroscopy or Hysterosalpingography

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Interventions

Group B (intervention group): Patient will be treated with the GnRh-analouge, triptorelin 0.1mg/day subcutaneously beginning in the mid luteal phase of the previous menstrual cycle and continuing

Group B (intervention group): Patient will be treated with the GnRh-analouge, triptorelin 0.1mg/day subcutaneously beginning in the mid luteal phase of the previous menstrual cycle and continuing till the date of embryo transfer. Full pituitary desensitization will be ensured by measuring serum estradiol on the first day of the menstrual cycle and should be less than 50 picogram /dl Endometrial preparation will begin from third day of menstruation by oral Estradiol valerate 8mg/day till endomtrium exceeding 8.5mm, then progesterone administration rectal suppository 400mg Am and intramuscular 100mg Pm.