RecruitingACTRN12613001339741

Right Ventricular Clearance Index (RVCI): A Simple New Parameter To Assess The Right Ventricular Systolic Function Using Contrast Echocardiography In Critically Ill Patients

Sponsor

Military Hospital Of Tunis

Enrollment

35 participants

Start Date

Dec 2, 2013

Study Type

Interventional

Conditions

Right Ventricular Dysfunction Assessment In Critically Ill Patients

Summary

The aims of this trial are to study the correlation between right ventricular clearance index(RVCI) and two classical echocardiographic parameters of the right ventricular systolic function: TAPSE and S’ and to test the ability of RVCI to predict right ventricular systolic dysfunction.

Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This study is testing a new measurement called the Right Ventricular Clearance Index (RVCI) — a way of assessing how well the right side of the heart is pumping blood, using a contrast echocardiogram (a heart ultrasound with a special dye). The goal is to see if this new measurement can accurately detect problems with the right side of the heart in critically ill patients. You may be eligible if: - You are 18 years or older - You are critically ill and being cared for in an intensive care unit (ICU) - You are sedated and on a breathing machine - You have a central venous catheter (a tube in a large vein, usually in the neck or chest) You may NOT be eligible if: - The ultrasound images of your heart are of poor quality through the chest wall - There are contraindications to the transesophageal (through the food pipe) echocardiography probe - The probe cannot be safely inserted - The central line tip is not positioned in the right atrium - You have a hole between the chambers of the heart (intracardiac shunt) - You have organic tricuspid valve regurgitation or prior surgery on the tricuspid valve Talk to your doctor about whether this trial might be right for you.

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Interventions

Patients undergo both transthoracic and transesophageal echocardiography performed by an experienced operator. The approximate duration of examination is 30 minutes. Both the transthoracic and transe

Patients undergo both transthoracic and transesophageal echocardiography performed by an experienced operator. The approximate duration of examination is 30 minutes. Both the transthoracic and transesophageal echocardiography are undertaken only one occasion. During transthoracic echocardiography, we measure TAPSE (tricuspid annular plane systolic excurtion), S' (tricuspid annular plane systolic peak velocity), and PASP (pulmonary artery systolic pressure). During the transesophageal echocardiography, we perform a contrast test by injecting 5 ml of ultrasound contrast agent as a bolus through the central venous catheter. The time taken by the contrast agent to totally disappear from the right ventricular is called T and is noted in seconds. The right ventricular clearance index (RVCI) is defined as follows: RVCI= (T/HR)*100 (HR = heart rate). The right atrial pressure (RAP) is measured using the central venous catheter. We will test correlations between RVCI, TAPSE and S'. We will also test correlations between RVCI, PASP and RAP We will study the ability of RVCI to detect right ventricular systolic dysfunction defined with TAPSE<16mm or S'<10cm/s

Locations(1)

Tunis, Tunisia

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ACTRN12613001339741