Colchicine for the Primary Prevention of Atrial Fibrillation after Cardiac Surgery: A Double Blind Placebo Randomised Controlled Trial

This study is testing whether colchicine (a medicine commonly used for gout and inflammation) can help prevent an irregular heart rhythm called atrial fibrillation (AF) that sometimes occurs after heart surgery. AF after surgery can cause complications, and researchers think colchicine's anti-inflammatory properties may reduce the risk. You may be eligible if: - You are over 18 years of age - You are having heart bypass surgery (CABG), aortic valve replacement (AVR), or both - You do not have a history of atrial fibrillation - You have a heart rhythm in sinus rhythm at the time of enrolment - Your kidney function is adequate (eGFR 35 mL/min or higher) - Your liver function is within acceptable limits - You are able to take oral medication within 72 hours after surgery You may NOT be eligible if: - You are allergic to colchicine or already taking it - You have severe liver disease - You have kidney function below the required level (eGFR less than 35 mL/min) - You have a muscle disease or elevated creatine kinase - You have a significant blood cell disorder - You have severe gastrointestinal disease - You are pregnant, breastfeeding, or of childbearing age - You have a known history of atrial fibrillation Talk to your doctor about whether this trial might be right for you.