Use of Carrageenan spray in the prevention of rhinovirus cold infection
A randomized placebo controlled trial of the preventative effects of Carrageenan nasal spray on reported cold infection symptoms and rhinovirus levels in the nose, when taken for 8 weeks by adults during cold season.
Julian Crane
80 participants
Apr 10, 2014
Interventional
Conditions
Summary
This is a pilot randomised control trial (RCT) to investigate whether using nasal Iota Carrageenan spray is protective against the development of colds caused by rhinovirus. The regular spraying of Iota Carrageenan may reduce the incidence of rhinovirus infections by blocking the binding of virus particles to nasal cells. If successful, the pilot study data will be used as the basis of a larger study to examine whether Iota Carrageenan can reduce rhinovirus infections among asthmatic adults.
Eligibility
Inclusion Criteria1
- At least one cold infection reported in the previous year
Exclusion Criteria2
- Not using any other nasal sprays during the study period
- Previous sensitivity to carrageenan spray.
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Interventions
A nasal spray containing saline solution and 1.6 mg/ml carrageenan will be taken by participants in the active group during cold season. Each participant will take one spray into each nostril 3 times each day for 8 weeks. The participants will take a daily record of cold symptoms and a nasal swab will be taken at the beginning and end of the study, as well as when cold symptoms develop, to ascertain levels of rhinovirus in the nose.
Locations(1)
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ACTRN12614000026628