RecruitingACTRN12614000086662

Resistance training with Partial Vascular Occlusion (VOT) in Inclusion Body Myositis (IBM). A single group interventional study: a pilot study to corroborate prior findings of VOT in the IBM population

Low intensity resistance training with blood flow to targeted muscles partially restricted: an effective strengthening regime for those with Inclusion Body Myositis?


Sponsor

Sir Charles Gairdner Hospital Physiotherapy Department

Enrollment

6 participants

Start Date

Jan 29, 2015

Study Type

Interventional

Conditions

Summary

To explore whether the relatively new form of resistance exercise which employs low resistances accompanied by restricting blood flood to targeted muscles (as know in Japan as Kaatsu training) can play a role in reducing the disability caused by inclusion body myositis.


Eligibility

Sex: Both males and females

Plain Language Summary

Simplified for easier understanding

This pilot study is testing whether a special type of exercise called blood flow restriction training (also called Kaatsu training) — which uses low weights combined with a gentle restriction of blood flow to the muscles — can help reduce weakness and disability in people with a muscle disease called Inclusion Body Myositis (IBM). IBM is a rare condition that causes progressive muscle weakness, particularly in the arms and legs. You may be eligible if: - You have a confirmed diagnosis of Inclusion Body Myositis - You can walk at least around the house (with or without an aid) - You have full ability to straighten your knee - You are willing to participate only in this study's exercise program for the duration (no other formal thigh-strengthening program) You may NOT be eligible if: - You cannot walk 10 metres - You have poor blood circulation in your legs or peripheral vascular disease - You have a coexisting neurological or psychiatric condition - You have severe kneecap pain or knee osteoarthritis - You have an unstable medical condition such as unstable angina, uncontrolled diabetes, or uncontrolled high blood pressure Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

1 hour, 3 times/per 18 week strength exercise program in 2 phases targeting the quadriceps muscles in people in IBM. Sessions will held in as a group and supervised by a senior physiotherapist in a t

1 hour, 3 times/per 18 week strength exercise program in 2 phases targeting the quadriceps muscles in people in IBM. Sessions will held in as a group and supervised by a senior physiotherapist in a tertiary hospital. Phase 1: establishing baseline. 5-6weeks of traditional moderate intensity strength training program (1 hour 3x/wk). Exercises: squats, leg extensions, inner range quadriceps exercises, leg press. repetitions: 8-12, 3 sets Load: approx 60% of maximum lift Phase 2: 12 weeks strength training at low intensity accompanied by partial occlusion of blood flow to quadriceps via blood pressure cuff placed around thigh. The cuff will remain inflated and around the thigh during exercises. exercises: as above repetitions: 15 load: 20-50% of maximum lift occlusion pressures: ~50% of systolic blood pressure


Locations(1)

WA, Australia

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