RecruitingACTRN12614000139673

Studying the effect of fibroids versus adenomyosis on the ovarian artery blood flow in comparison to normal subjects.

comparative study of the ovarian vascular indices in women with fibroids and adenomyosis and women without using ultrasound 3D power Doppler

Sponsor

Eman Elkattan

Enrollment

150 participants

Start Date

Jul 3, 2014

Study Type

Interventional

Conditions

-women with adenomyosis detected by ultrasound and confirmed by histopathology -women with fibroid uterus detected by ultrasound and confirmed by histopathology

Summary

we studied the ovarian vascular indices in women who were diagnosed of having either fibroids or adenomyosis by ultrasound and who had hysterectomy in comparison for age-matched women who have a free ultrasound examination

Eligibility

Sex: FemalesMin Age: 25 YearssMax Age: 55 Yearss

Plain Language Summary

Simplified for easier understanding

This observational study is looking at blood flow in the ovarian arteries in women who have been diagnosed with uterine fibroids or a condition called adenomyosis (where the inner lining of the uterus grows into the muscle wall), compared to women with no uterine abnormalities. Participants will have an ultrasound scan to measure blood flow. Researchers want to understand how these conditions affect blood supply to the ovaries. You may be eligible if: - You are a woman aged between 25 and 55 years - You have an ultrasound diagnosis of fibroids only (and are scheduled for a hysterectomy confirmed by pathology), OR - You have an ultrasound diagnosis of adenomyosis only (and are scheduled for a hysterectomy confirmed by pathology), OR - You have a normal pelvic ultrasound and no symptoms, and are close in age to the other participants You may NOT be eligible if: - You have both fibroids and adenomyosis - You have fibroids or adenomyosis but are not having a hysterectomy Talk to your doctor about whether this trial might be right for you.

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Interventions

trans-vaginal 3D power Doppler Ultrasonographic examination was done by Voluson 730 Registered trademark , Expert ultrasound system (GE Healthcare, Zipf, Austria) with transvaginal 5-to 9-MHz volume transducer,).The ultrasound examination was preformed prior to hysterectomy. The ultrasonographic examination provided data related to vascular index (VI), flow index (FI), and vascular-flow index (VFI). The region of interest included the entire region of the ovary.After evaluating the total color percentage and flow amplitude for the volume of interest, The virtual organ computer aided analysis (VOCAL) software for the analysis of 3D power Doppler histograms was used with computer algorithms to form indices of blood flow and vascularization. In the 730 system, there are four rotation angles to choose from, namely, 6 degrees, 9 degrees , 15 degrees , and 30 degrees, and because the entire data set is rotated about 180 degrees, these result in 30, 20, 12, and 6 planes, respectively, being available for measurements.We used rotation angle 30 degrees in this study .That means rotation in 6 planes manually.The approxiamate time of the test from 15-20 minutes.

Locations(1)

Cairo, Egypt

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ACTRN12614000139673