Evaluation of the efficacy of intradermal onabotulinumtoxinA for the treatment of accordion (cheek) wrinkles: A 2-centre randomized double-blinded split face clinical trial

This study is testing whether tiny injections of Botox (onabotulinumtoxin A) into the cheek skin can reduce the appearance of accordion-style wrinkles that appear when you smile. It is a split-face trial, meaning one side of the face gets the real treatment and the other side gets a placebo, so each person acts as their own comparison. Researchers will measure wrinkle improvement, skin elasticity, and patient satisfaction. You may be eligible if: - You are between 40 and 75 years old - You have visible cheek (accordion) wrinkles you want treated - Your wrinkles are at least grade 1 at rest or when smiling widely - You are mentally able to give your own consent - You are able to attend follow-up appointments for the duration of the study - If you take low-dose aspirin (81 mg), you are willing to stop it two weeks before the trial You may NOT be eligible if: - You are pregnant or breastfeeding - You have previously had Botox injections in your cheeks - You have had an allergic reaction to botulinum toxin before - You have had ablative laser treatment on your cheeks - You have had non-ablative laser treatment on your cheeks in the last 6 months - You have had surgery in your cheek area - You have a muscle or nerve disease such as myasthenia gravis or ALS Talk to your doctor about whether this trial might be right for you.