Investigation of the effects of anaesthetic choice on ventilation-perfusion scatter and lung gas exchange.
A parallel group randomised comparison study of the effects of TIVA propofol versus inhalational sevoflurane anaesthesia on lung ventilation-perfusion matching and gas exchange, in patients undergoing general anaesthesia for surgery requiring relacant GA with an arterial line for cardiovascular monitoring.
Austin Health
24 participants
Feb 2, 2015
Interventional
Conditions
Summary
The relative effects on V/Q matching in the lung of modern inhalational anaesthetics such as sevoflurane have not been compared with those of the intravenous agent propofol. There are potentially important implications for the management of patients with reduced lung function undergoing surgery.
Eligibility
Inclusion Criteria1
- Patients undergoing general anaesthesia for surgery requiring relacant GA with an arterial line for cardiovascular monitoring.
Exclusion Criteria1
- Severe impairment of lung function. (FEV1 or FVC less than 30% predicted), or morbid obesity (Body mass index (BMI) greater than 40 kg/m2)
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Interventions
Total intravenous anaesthesia with propofol, titrated against depth of anaesthesia measured using bisepectral index (BIS 40-60).
Locations(1)
View Full Details on ANZCTR
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ACTRN12614000226606