Effect of activity after eating on blood glucose concentration in a group of young adults
Effect on glycaemia of postprandial activity at 5 and 30 minutes in a healthy adult population: randomised crossover study
University of Otago
90 participants
Feb 28, 2014
Interventional
Conditions
Summary
The aim of this study is to evaluate the effect of very low intensity physical activity on blood sugar levels in healthy adults, after eating. It is a commonly controlled for belief in studys on glycaemia that very light activities such as standing and walking after eating may impact the blood sugar response to a meal. We aim to test this by comparing group data of a sedentary control against very light physical activity at 5 and 30 minutes after eating. We will be examining the 2 hours directly after the consumption of 2 serves of bread. A secondary aim is to evaluate the potential of a relationship in fasting blood glucose and the level of glycated albumin, a blood protein, in healthy adults. Fasting blood glucose is marker of short term glycaemic control, where glycated albumin is an emerging mid-term marker of glycaemic control. A positive correlation or relationship between the two markers will further affirm the credibility of glycated albumin for use in glycaemic monitoring and surveillance.
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Interventions
Healthy overnight (10 hour) fasted adults will be given a test meal of white bread containing 50g of available carbohydrate. The protocol for GI testing of a food product will be followed, with capillary blood samples take at baseline, 15, 30, 45, 60, 90 and 120 minutes post meal ingestion to observe changes in blood glucose levels over this time. These data points will be used to determine each participants (n=90) incremental area under the curve (iAUC) of blood glucose as a response to meal ingestion. This process will be repeated for each participant as part of a crossover design with a two week washout, with one arm a control in which participants remain sedentary for 2h after eating. For the other study arm participants will use a seated exercycle at low RPM and low resistance for ten minutes after 5 or 30 minute after finishing eating. (n=90 control, N=45 cycle at 5mins, n=45 cycle at 30mins). the process will be randomized by both order of intervention and timing of exercise. A secondary element to this study will compare baseline fasted blood glucose capillary measures (captured as part of the iAUC process) with glycated albumin (GA), a mid-term marker for glycaemic control. A possible correlation between fasted blood glucose, postprandial glucose (sedentary condition) and GA will be reviewed. GA assessment will be undertaken on frozen samples of participant blood (taken by capillary as part of the iAUC process) after the intervention has occurred. Participants will have access to their own data, investigators will de-identify and use pooled data for group analysis.
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ACTRN12614000264684