A Prospective Study of the Effects of Pregabalin versus Placebo on the incidence and intensity of pain after video-assisted thoracoscopic surgery.
A Prospective Study of the Effects of Pregabalin versus Placebo on the incidence and intensity of pain after thoracoscopic surgery
Dr Alex Konstantatos
95 participants
Oct 10, 2007
Interventional
Conditions
Summary
The study proposes to investigate whether a drug with specific effects which damp excessive nerve mediated activity can prevent the long term occurence of pain after chest surgery.
Eligibility
Inclusion Criteria3
- Patients having video assisted thoracoscopic surgery (VATS)
- Conscious
- Able to understand use of "PCA" ( Patient Controlled Analgesia)
Exclusion Criteria7
- Morphine or paracetamol contraindication or allergy
- Allergy to pregabalin
- History of chronic pain
- Evolving myocardial infarction, arrhythmias at time of surgery
- Preoperative respiratory function tests showing a forced vital capacity<60% predicted, forced expiratory volume 1s <60%, or both
- Renal insufficiency (creatinine >15mg/dL)
- Liver dysfunction (aspartate aminotransferase, alanine aminotransferase, or both >40u/L)
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Interventions
prevention of long term pain following thorocotomy operation. Intervention involves using 300mg oral pregabalin administered prior to commencement of thoracoscopic surgery (day 1) and continued for a further 5 postoperative days (day 6). Both preoperative pregabalin and postoperative pregabalin are compared with oral placebo. Blinded nursing staff in hospital administering pregabalin/placebo will sign medication chart to confirm that the pregabalin/placebo has been taken by the participant.
Locations(1)
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ACTRN12614000554662