ActivePhase 4ACTRN12614000559617

Does short compared to long ureteral stenting following pyeloplasty offer comparable periinterventional and functional outcomes?

Does a two weeks compared to a six weeks ureteral stent indwelling time following minimally invasive pyeloplasty in patients with uretero-pelvic-junction obstruction offer comparable periinterventional and functional outcomes? Long term data from a prospective randomized trial


Sponsor

Department of Urology, University of Berne

Enrollment

82 participants

Start Date

May 1, 2007

Study Type

Interventional

Conditions

Summary

First described in 1993, laparoscopic pyeloplasty has largely replaced the open reconstructive procedure described by Anderson-Hynes. Mimicking the open approach, the minimally invasive technique offers equivalent success rates (87-100%) with minimal morbidity. The use of transanastomotic stents following pyeloplasty remains a debated issue. While nowadays some surgeons even promote a stentless procedure despite a relatively high prolonged urinary leakage risk and the need for secondary interventions, the majority of urologists still uses some sort of transanastomotic stents. However, there exists no consensus on optimal stent indwelling time which ranges somewhere between 1 week and 2 months. Furthermore, ureteric stents are not free of complications and side effects and therefore, stent indwelling time is an important issue. Until recently stents were typically removed at the surgeon’s discretion because there was no data on optimal stent indwelling time available. Fortunately, there exists one recent prospective randomized trial suggesting that 1 week stenting is non inferior to 4 week stenting in terms of functional outcomes. However, this study lacks a rigid and long term follow up and therefore, the question of long-term safety/success after a short stenting time remains unanswered (One-week versus four-week stent placement following laparoscopic and robot assisted pyeloplasty - Results of a prospective randomized single-center study. Danuser H et al. BJU Int. 2014 Jan 28. doi: 10.1111/bju.12652.). Similarly, our study aimed to investigate the impact of a short (2 weeks) compared to a long (6 weeks) ureteral stent indwelling time. In contrast to the above mentioned trial, we follow our patients meticulously over years including scintigraphies and are therefore able, to provide perioperative data as well as robust long term functional results. In addition, we aimed to identify patients factors predicting the postoperative function of the affected kidney.


Eligibility

Sex: Both males and females

Inclusion Criteria2

  • Patients diagnosed with urodynamic relevant uretero-pelvic junction obstruction
  • Informed consent

Exclusion Criteria2

  • Conversion to open surgical procedure
  • Missing follow up information

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Interventions

All patients underwent routine physical examination, total blood count, serum biochemistry, and urine analysis and culture prior to surgery. Preoperatively, baseline split kidney function (scintigraph

All patients underwent routine physical examination, total blood count, serum biochemistry, and urine analysis and culture prior to surgery. Preoperatively, baseline split kidney function (scintigraphy) was assessed. Additionally, surgery was planned based on either contrast enhanced CT-scan or intravenous urography. Patients received 1.2g amoxicillin and clavulanic acid as perioperative prophylaxis. Routinely, retrograde examination with consecutive ureteral stent (DJ stent) insertion was performed immediately prior to pyeloplasty with the patients already under general anesthesia. Focusing on the main surgical procedure (pyeloplasty), we apply a minimally invasive (pure laparoscopic or robotic assisted laparoscopic) transperitoneal approach using four trocars and the following steps: Initially, the colon is mobilized and reflected. Once the ureter is identified, it is chased to the renal pelvis in order to identify eventually crossing lower pole vessels. Thereafter the ureter is transected at its origin from the renal pelvis and the strictured proximal segment spatulated over 1,5cm. Routinely, the enlarged renal pelvis is reduced in size. With the help of three stay sutures, the uretero-pelvic anastomosis is sawn. Finally, the re-dimensioned pyelon is closed with a running suture and water tightness tested by i.v. Furosemide application. The anastomosis is covered with surrounding tissue/Gerota’s fascia and a drain routinely placed at the anastomosis. The drainage is typically removed if the drained volume is < 20ml/24 hours. The Foley catheter remains for 5 days. In open surgery, ureteral stents were typically removed one week after pyeloplasty (Dobry E, Usai P, Studer UE, Danuser H. Is antegrade pyeloplasty really less invasive than open pyeloplasty? Urologia internationalis. 2007;79(2):152-6). However, nowadays, pyeloplasties are mainly performed through a minimally invasive approach. Fundamentally, DJ stent indwelling time is surgeon dependent and varies somewhere between 1 week and 2 months according to the available literature. While we used to keep the stents for 6 weeks after pyeloplasty in earlier days, this policy has changed over time to a shorter indwelling time around 2 weeks. We therefore aimed to investigate the evantual impact of a short (group A: 2 weeks) compared to a long (group B: 6 weeks) DJ stent indwelling time. DJ-stents were removed in the outpatient clinic after 2 (group A) and 6 weeks (group B), respectively.


Locations(1)

Berne, Switzerland

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ACTRN12614000559617