In women with unexplained recurrent abortion, is prophylactic use of low dose aspirin and Calheparin more effective than no treatment in increasing the number of patients who complete their first trimester?
Ahmed Maged
180 participants
Jun 1, 2011
Interventional
Conditions
Summary
to study the effect of prophylactic use of low dose aspirin and heparin on patients with recurrent unexplained pregnancy loss Methods: prospective case control study conducted on 180 pregnant women randomized into 2equal groups. Group 1 received low dose aspirin 75 mg and heparin 5000 IU subcutaneous every 12 hours. Group 2 received no treatment
Eligibility
Inclusion Criteria2
- Gestational age 5-7 weeks
- history of three or more spontanous abortions without an obvious cause
Exclusion Criteria5
- Participants with documented cause of recurrent abortion as antiphospholipid syndrome
- history of thrombo-embolic manifestations
- medical disorder as diabetes or hypertension
- chronic disorder like renal cardiac or liver disease
- those with structural anomalies of the uterus
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Interventions
180 pregnant women with history of recurrent unexplained pregnancy loss classified into 2 groups Group 1 included 90 women received low dose aspirin orally 75 mg once daily and heparin 5000 IU subcutaneous every 12 hours started at 8 weeks gestation till the end of 12th week. Group 2 included 90 women received no treatment. Monitoring adherence to treatment was done by counting drug tablets return and counting number of used syringes every 2 weeks
Locations(1)
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ACTRN12614000698673