Administering Gonadotrophin Releasing Hormone (GnRH) Agonists during the Luteal Phase in Artificial Cycle Frozen-Thawed Embryo Transfers

The aim of this study is to evaluate the benefit of - two sub cutaneous injections of GnRH agonists (tryptorelin 0.1 mg) administred on the 4th day and on the 6th day following the introduction of progesterone - In addition to usual progesterone supplementation (3 pills of 200 mg per day administred vaginally, 1 in the morning, 2 in the evening) The oestradiol supplementation was starded on the first day of the cycle : - From the first day to the 5th day of the cycle, they took 2 pills containing 2 mg of estradiol a day -From the 6th to the 10th day of the cycle, they took 3 pills containing 2 mg of estradiol a day. - They then took 4 pills containing 2 mg of estradiol a day until the pregnancy test. Oestrogen was first administered orally, then vaginally, following menstruation. Test were performed on the 13th day (blood test and ultrasonography). The progesterone was introduced when all conditions are met : The endometrium over 6 mm in thickness, pulsatility indexes below 3, and oestrogen levels above 750 pg/ml. If these conditions weren’t met, a 2nd test and up to a 3rd test were conducted, where oestrogen doses could be increased (increasing the dose to 5 or 6 pills a day). A pregnancy test (Human Chorionic Gonadotropin (HCG) assay) was conducted 16 days after the introduction of progesterone. Patients continued to take oestrogen and progesterone during the first three months of the pregnancy if this test was positive.