RecruitingACTRN12614000829617

Effect of Blackcurrant consumption and physical fatigue on cognitive performance.

Relationship between the consumption of a blackcurrant supplement and exercise-induced fatigue on mental acuity and cognitive performance in healthy volunteers.


Sponsor

New Zealand Institute for Plant and Food Research

Enrollment

60 participants

Start Date

Sep 1, 2014

Study Type

Interventional

Conditions

Summary

Physically active individuals have a faster and more robust cognitive processing ability than those who are sedentary. Meta analysis of randomized controlled studies, involving individuals of different ages, showed that physical exercise (even after one session) can improve mental acuity. Exercise intensity is generically thought to affect cognitive performance in an upside down, U-shaped fashion; moderate intensity exercise facilitates cognitive functioning, whereas high intensity training (HIT) may delay or impair cognition. Whilst prolonged high intensity training sessions does appear to have detrimental action on mental acuity, a recent study showed that short bursts (60 secs) of HIT improved cognitive execution. These conflicting findings suggest that the duration of the physical “fatiguing” exercise and an individual’s ability to recovery may impact upon their cognitive functioning. Although the underlying mechanisms involved in how exercise improves or preserves cognitive ability is unclear, cerebral blood flow is integral to mental acuity: A positive link between aerobic exercise, delivery of oxygenated haemoglobin to the cerebral frontal area and enhanced cognition has recently been shown. Since prolonged high intensity anaerobic exercise is shown to cause a transient decrease in the cerebral oxygenated: deoxygenated haemoglobin ratio and a delay in the removal of detrimental metabolites (e.g. lactate), changes in blood flow and oxidative stress may underlie the impaired cognitive function observed. We have shown that blackcurrant consumption alleviates oxidative stress and improves blood flow to a variety of tissues; increasing oxygen delivery to tissues and blood lactate clearance in various exercise training scenarios. It is therefore feasible that blackcurrant consumption may alleviate oxidative stress, facilitate oxygen delivery to and removal of waste by-products from, the brain during recovery from a physical “fatiguing” exercise, thereby preserving cognitive function. In this study we examine the inter-relationship between (i) cognitive performance (ii) an intensive “fatiguing” exercise and (iii) “timed” consumption of a single portion of a blackcurrant extract.


Eligibility

Sex: Both males and femalesMin Age: 16 YearssMax Age: 50 Yearss

Plain Language Summary

Simplified for easier understanding

This study looks at whether consuming a blackcurrant extract before exercise can help protect brain function after an intense workout. Researchers believe blackcurrants may reduce oxidative stress and improve blood flow to the brain, helping people think more clearly even after hard physical activity. You may be eligible if: - You are between 19 and 50 years old (note: minimum stated in criteria is 19, though 16 is listed in the registry fields) - You are generally healthy, male or female - You have not done formal fitness training for at least 4 months - You are able to complete a high-intensity cycle test (Wingate test) You may NOT be eligible if: - You are allergic or sensitive to blackcurrants or berry products - You have a health condition that prevents you from exercising safely (heart, back, joint, or breathing problems) - You have eye problems, color blindness, epilepsy, or aura migraines that would affect computer-based cognitive tests - You are pregnant or planning to become pregnant - You take medications that affect blood properties - You have high or low blood pressure, recent illness, or blood-borne diseases Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

This is a full factorial study design that will allow us to test the effect of both physical fatigue and efficacy of blackcurrant nutritional intervention on cognitive performance as well as identify

This is a full factorial study design that will allow us to test the effect of both physical fatigue and efficacy of blackcurrant nutritional intervention on cognitive performance as well as identify potential interactions. Participants will be randomised into one of the four treatment groups; Group 1; placebo and no exercise, Group 2; placebo and intensive “fatiguing” exercise, Group 3; blackcurrant extract and no exercise and Group 4; blackcurrant extract and intensive “fatiguing” exercise. The blackcurrant extract used in this study is made commercially by Just-the-Berries (Nelson, NZ), and is an anthocyanin rich (freeze-dried) extract (30%) made entirely of New Zealand Blackcurrants. Furthermore, the dose used in this study is ~ 1g (equivalent to 250 mg anthocyanins). On the day of the trial, participants will be asked to consume a gelatine capsule containing either a blackcurrant extract or placebo (equivalent fructose and glucose), after 1 hour they will be asked to either to relax for 10 minutes or perform Wingate cycle test (30 second cycle at maximum power [80-100 watts] on a stationary ergometer with a 4% body weight braking torque) with a 1 min resting interval until they fatigue (usually 4-5 repeats); indicated by a drop in power output in the last 10 seconds of the 30 second cycle or verbal indication by the participant. The participant will then be asked to repeat the cognitive performance task followed by another 30 second “Wingate” test using the same conditions described above.


Locations(1)

Palmerston North, Manawatu, New Zealand

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ACTRN12614000829617