Effectiveness of community level mass drug administration using Albendazole against Taenia solium (pork tapeworm) and other Soil Transmitted Helminths among communities in northern Lao People's Democratic Republic.
Effect of community level Mass Drug Administration against Taenia solium and Soil Transmitted Helminths on parasite burden among communities in northern Lao People's Democratic Republic
Australian Animal Health Laboratory
300 participants
Oct 25, 2013
Interventional
Conditions
Summary
To explore the risk factors for transmission and the socioeconomic impact of pig-associated zoonotic diseases in Lao PDR, developing recommendations for “catch-all” control measures that will impact multiple diseases, and thereby improve biosafety and limit disease transmission to the human population. In particular: Develop and trial strategies to better define and manage the risk from zoonotic disease at pilot sites within each production-market chain Trial a package of human and animal intervention strategies directly targeted at breaking the lifecycle of pork tapeworm (Taenia solium) - including administration of worm tablets to the total human population (n=300) of this study site
Eligibility
Inclusion Criteria1
- Any healthy person, male or female, over 6 years old that has given informed consent either personally or via the parent/guardian. People with a cognitive impairment, mental illness or intellectual disability (as indicated by family members) may be recruited as neurocysticercosis is able to cause such conditions.
Exclusion Criteria1
- Less than 6 years of age, severe illness, non-consenting
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Interventions
Trial a package of human and animal intervention strategies directly targeted at breaking the lifecycle of pork tapeworm (Taenia solium). The human package consists of Abendazole 400mg administered orally once daily for 3 consecutive days, offered to all eligible human participants (n~300) of this study site and repeated again at a six month interval. This dose regime was administered by a team of qualified medical personnel visiting each household individually to explain life cycle and reason for intervention, along with distribution of education materials, soap and water buckets in order to allow participants to make an informed decision regarding participation, and provide a post treatment faceal sample in a safe way. Response to antihelmintic treatment is measured by comparing pre and post treatment parasite burdens on a subset of the population through combination ELISA, microscopy and PCR techniques. Ongoing social research approaches have been measuring the change in Knowledge, attitudes and pratices (KAP) and response to the intervention.
Locations(1)
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ACTRN12614001067662