Systemic vs. topical Reparil 'Registered Trademark' for the treatment of Temporomandibular Joint and Masticatory Muscle Pain

This study is comparing two forms of a medication called Reparil — one taken as a tablet and one applied as a gel — for treating pain in the jaw joint (temporomandibular joint or TMJ) and the muscles used for chewing. A placebo (dummy treatment) group is also included for comparison. The goal is to find out which form of Reparil works better and is better tolerated. You may be eligible if: - You are between 18 and 65 years old - You have self-reported facial ache or pain in the jaw muscles, jaw joint, or in front of the ear - You have a clinical diagnosis of a temporomandibular disorder (TMD) based on research diagnostic criteria - Your jaw joint pain has been present for at least 1 month on most days You may NOT be eligible if: - You have infectious arthritis, crystal-induced arthropathy, or another musculoskeletal disorder - You have a primary diagnosis of myofascial pain - Your headaches are primarily due to migraine or another specific head pain condition - You have an active infection in your teeth, ears, eyes, nose, or throat - You have untreated depression or unstable antidepressant medication - You have dental disease requiring ongoing treatment - You are pregnant or breastfeeding - You are sensitive to any ingredient in Reparil Talk to your doctor about whether this trial might be right for you.