Efficiency and safety of preoperative Tranexamic acid in reducing perioperative blood loss in elective cesarean section
Efficiency and safety of preoperative Tranexamic acid compared to a placebo in reducing perioperative blood loss in women undergoing elective cesarean section
Ahmed Maged
200 participants
Nov 1, 2013
Interventional
Conditions
Summary
A randomized placebo-controlled prospective study involved 200 women undergoing elective LSCS randomized to receive either 1 gm TA 15 min before CS (TA group) or glucose 5% (Placebo group). Complete blood count (CBC) was done before CS and 24 hours later. The pre- and postoperative hematocrit values and maternal weight were used to calculate the estimated blood loss (EBL) during CS which was the primary outcome measure.
Eligibility
Inclusion Criteria1
- full-term singleton pregnancies underwent elective lower segment caesarean section
Exclusion Criteria5
- prolonged CS (> 90 min according to anesthetic record), 2.anemic patients (Hb < 9 gm %),
- presence of maternal medical disorder (e.g. cardiac, renal, hepatic & coagulopathies) or
- history of thrombo-embolic events.
- known allergy to TA.
- Patients with increased risk for obstetric hemorrhage (e.g. antepartum hemorrhage, abnormal placentation, previous history of uterine atony & postpartum hemorrhage, polyhydramnios & uterine fibroids).
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Interventions
1 gm tranexamic acid 15 min before CS by intravenous infusion
Locations(1)
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ACTRN12615000312549