CompletedPhase 4ACTRN12615000322538
Comparative plasma and cerebrospinal fluid pharmacokinetics of paracetamol following intravenous and oral administration
Plasma and cerebrospinal fluid concentrations of 1 g intravenous paracetamol compared with 1 g and 1.5 g oral paracetamol in adult surgical patients
Sponsor
Royal Melbourne Hospital
Enrollment
21 participants
Start Date
Feb 22, 2008
Study Type
Interventional
Conditions
Summary
The primary purpose of this study was to determine the concentrations of the drug paracetamol in the plasma and cerebrospinal fluid after intravenous and oral administration to adult patients having surgery under spinal anaesthesia.
Eligibility
Sex: Both males and femalesMin Age: 18 Yearss
Inclusion Criteria5
- aged 18 years and over
- presenting for elective surgery under spinal anaesthesia
- able to communicate in English
- no contraindication to paracetamol
- no paracetamol within previous 12 hours
Exclusion Criteria5
- aged <18 years
- not planned for spinal anaesthesia
- unable to communicate in English
- contraindication to paracetamol
- paracetamol within previous 12 hours
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Interventions
Single bolus dose of 1 g intravenous paracetamol given immediately before induction of spinal anaesthesia
Single bolus dose of 1 g intravenous paracetamol given immediately before induction of spinal anaesthesia
Locations(1)
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ACTRN12615000322538