Repeatability and diurnal variation of eye responses measured with Neuro-Ophthalmic Device (NODe)

The NODe is a pre-release, prototype table top imaging device that consists of visual stimulus presentations through a standard tablet (iPAD like) and imaging hardware mounted inside of an enclosure which includes a nose-bridge and a chin-rest for patient alignment. The device intends to test neuro-pathology such as mild traumatic brain injury (mTBI or concussion) by assessing eye movements and pupil reactions in response to different visual stimuli presented on the tablet screen. The NODe has several features, including a very high frame capture rate that permit acquisition of highly-detailed data on direction of eye gaze and pupil diameter. The operator will instruct the participant on how the NODe exam will occur, including what to expect from the visual stimuli and how long the exam should take. Each test consists of a series of targets that the subject must follow with their gaze or a series of light flashes that will be presented while the participant focuses on a static target. The study will be conducted in two phases with each phase including 10 participants. The initial visit will include the participant performing the NODe tests repeatedly for 10 times, while the remaining 6 visits (2 visits per day) will test diurnal variation and will run NODe set of tests once in each visit. The initial visit may take up to 2 hours, while the remaining 6 visits will take up to 15 minutes each to complete. The visits need not necessarily be on consecutive days, but will be conducted within the time period of a fortnight.