Effect of adding ketamine infusion to propofol sedation on hemodynamic changes and recovery in patients undergoing elective lower limb surgery under spinal anaesthesia
Addition of ketamine infusion to propofol sedation with spinal anesthesia in patients undergoing elective lower limb surgery: Hemodynamic changes, Recovery Profile
Aysu Hayriye Tezcan
61 participants
Jul 7, 2014
Interventional
Conditions
Summary
We tried to evaluate the difference between two sedation drugs with the route of ; propofol alone intravenous infusion and ketamine-propofol combined intravenous infusion. We studied during lower limb surgery with spinal anesthesia. And observed patients hemodynamic values, mini mental state examination scores, postoperative events, satisfaction scores.
Eligibility
Inclusion Criteria4
- -80 years old
- Both gender
- Candidate of elective lower limb surgery
- Do not have contraindications for spinal anesthesia
Exclusion Criteria1
- Patients with a allergic reaction to propofol or ketamine, obesity (BMI greater than or equal to 35) , uncontrolled hypertension ( greater than 170/100mmHg), clinically significant cardiac, pulmonary, hepatic, renal dysfunction, psychiatric disorders, neurologic impairment were exluded from study.
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Interventions
Intravenous infusions of propofol alone and ketamine combined with propofol during sedation. In group P: Propofol infusion dose is 25-75 mcg/kg/min and titrated according to Ramsey Sedation Score. In group KP: Propofol was managed like in Group P and ketamine dose is 1/3 of propofol in terms of mg.
Locations(1)
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ACTRN12615000372583