Comparative effect of resuscitation with hypertonic saline versus normal saline after extracorporeal circulation during cardiovascular surgery in the Intensive Care Unit (ICU)
Comparative effect of resuscitation with hypertonic saline versus normal saline on lactate clearance in patients hospitalized in ICU that underwent extracorporeal circulation during valve replacement or coronary artery bypass grafting
Ray Mendoza Franco
102 participants
Apr 18, 2013
Interventional
Conditions
Summary
This is a randomized double blind controlled trial that compares 7.5% hypertonic saline solution versus normal saline solution, in the resuscitation of the patients that underwent extracorporeal circulation surgery once they arrive in the ICU. The primary endpoint was to assess the lactate clearance within each arm of the study.
Eligibility
Inclusion Criteria2
- Patients with signed informed consent older than 18 years old
- Patients admitted in the ICU after valve replacement surgery or coronary artery bypass surgery that underwent extracorporeal circulation
Exclusion Criteria3
- Patients that withdraw the informed consent by himself or by their family at any time during the intervention
- Heart transplant surgery
- Patients that do not fulfill the study protocol
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Interventions
We administer intravenously infused over 30 minutes Hypertonic Saline with a concentration of 7.5% in a dose of 4 cc x kg of predicted body weight when the patients arrive to the ICU after a replacement valve surgery or a coronary artery bypass graft surgery that underwent extracorporeal circulation.
Locations(1)
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ACTRN12615000466549