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RecruitingPhase 2ACTRN12615000538549

Effect of lumbar anaesthesia on sympathetic activity below the level of the block

Area under curve of the photoplethysmographic signal as the evaluation measure for sympathetic activity during lumbar epidural anaesthesia

Sponsor

Clinical Hospital Center Zagreb

Enrollment

40 participants

Start Date

May 4, 2015

Study Type

Interventional

Conditions

sympathetic activity during lumbar epidural anaesthesia

Summary

Photoplethysmographic signal reflects sympathetic activity under the level of epidural block. The height of sensory block during epidural anaesthesia reflects the height of sympathetic block. Area under the photoplethysmographic curve (AUC) depends on variability of the photoplethysmographic signal strenght and duration. Our hypothesis is that change in any parameter, due to the sympathetic block, will change the area under the curve of the photoplethysmographic signal. 40 patients with epidural anaesthesia will be included in the research. 0.5% bupivacaine will be injected in the L3/L4 level and Biopac SS4LA Pulse Plethysmograph Transducer will be used for photoplethysmography recording. Amplitude (maximum PPG sygnal), pulse transit time and area under the curve will be recorded. Our goal is to test sympathetic activity using variabilities, shapes and characteristics of the PPG curve (area under the curve) during 0.5% bupivacaine epidural anaesthesia.

Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 45 Yearss

Plain Language Summary

Simplified for easier understanding

This study is looking at how spinal (epidural) anaesthesia affects blood vessel activity in the legs, as measured by a non-invasive finger sensor. Researchers hope to better understand the relationship between the level of the nerve block and circulation changes below that level. You may be eligible if: - You are between 18 and 45 years old - You are scheduled for surgery under epidural anaesthesia You may NOT be eligible if: - The pulses in the arteries of your feet and ankle cannot be felt - You do not sweat in your feet (a sign of nerve damage) - You have abnormal toenail growth or transparency - You have signs of disease in the blood vessels of your lower limbs Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Only one group of patients was included in the study. 0.5% bupivacaine was injected in the L3/L4 level by the qualified anaesthesiologist and Biopac SS4LA Pulse Plethysmograph. Photoplethysmography re

Only one group of patients was included in the study. 0.5% bupivacaine was injected in the L3/L4 level by the qualified anaesthesiologist and Biopac SS4LA Pulse Plethysmograph. Photoplethysmography recordings were taken before lumbar epidural anaesthesia procedure was done, as well as during the whole surgical procedure and during the post-anaesthesia recovery (until all of the sensoric functions of the lower limbs were recovered). Transducer was used for photoplethysmography recording. Amplitude (maximum PPG sygnal), pulse transit time and area under the curve were recorded.

Locations(1)

City of Zagreb, Clinical Hospital Center Zagreb, Croatia

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ACTRN12615000538549