CompletedPhase 3ACTRN12615000620527

Postprandial effect of krill oil supplementation in healthy female subjects

Investigation of the postprandial effect of krill oil supplementation on fatty acid metabolism and cardio-metabolic risk factors in healthy females

Sponsor

Victoria University

Enrollment

15 participants

Start Date

Jul 15, 2014

Study Type

Interventional

Conditions

Metabolic and Endocrine disorders

Summary

The health benefits of long-chain n-3 polyunsaturated fatty acids from krill oil and fish oil are associated with the incorporation of EPA and DHA into the cell membrane which then alters the membrane structure and cell functions. Consequently they reduce plasma triglyceride level and inhibit inflammatory response. The bio-availability of these fatty acids from the two oils maybe different due to the binding of fatty acids in the oils. This study will evaluate the incorporation of EPA and DHA into the plasma and chylomicron after a single dose supplementation. In addition the effects on cardio-metabolic risk factors will also be investigated.

Eligibility

Sex: FemalesMin Age: 18 YearssMax Age: 45 Yearss

Inclusion Criteria1

Healthy females aged 18-45 years and have not experienced menopause, body mass index (BMI) between 20 and 30 (kg/m2).

Exclusion Criteria1

Cigarette smoker; all types of heart, liver or kidney disease, diabetes; pregnancy; lactating; medications of cholesterol lowering, antihypertension, anti-inflammation, anti-coagulation or anti-depression; omega-3 or antioxidant supplements in the past four weeks prior to the study.

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Interventions

Ingestion of 5 x 1g krill oil capsules (containing 833 mg EPA + 471 mg DHA) with breakfast once (in the teaching clinic) followed by 1 week washout period, and Ingestion of 5 x 1g of fish oil capsule

Ingestion of 5 x 1g krill oil capsules (containing 833 mg EPA + 471 mg DHA) with breakfast once (in the teaching clinic) followed by 1 week washout period, and Ingestion of 5 x 1g of fish oil capsules (containing 1037mg EPA + 745 mg DHA) with breakfast once (in the teaching clinic) followed by 1 week washout period. Standardised breakfast (150g mashed potatoes with 600mL water) is provided. The breakfast is mixed with the intervention oil by the researcher before serving to the participants. Therefore adherence ensured.

Locations(1)

VIC, Australia

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ACTRN12615000620527