Effects of sugar-sweetened drinks on psychological and metabolic outcomes.
Possible effects on healthy young adults of sugar- and artificially-sweetened drinks in terms of psychological and metabolic outcomes
Professor Robert Boakes
153 participants
Apr 11, 2016
Interventional
Conditions
Summary
Background. Various lines of evidence indicate that negative metabolic consequences follow when a person regularly drinks a large quantity of sugar-sweetened beverages (SSBs). What is not known is whether SSBs also produce negative psychological effects, such as impairments in short-term memory and increased impulsiveness. Switching from SSBs to ‘diet’ beverages (non-nutritive sweetened beverages; NSBs) would seem to offer a relatively easy dietary change. However, it has been claimed that this can be counter-productive in at least some circumstances. Aims. 1. To test whether SSB consumption produces impairment on psychological tests, relative to NSB consumption and a water control condition; 2. To test whether the effects of NSB consumption depends on other aspects of a person’s diet (e.g. consumption of sweet energy-rich foods). Design. In a non-blinded 3-group parallel design over a 12-week period the Sugar group is given SSBs, the Diet group is given NSBs and the Water group is given water. Metabolic and cognitive/behavioural measures are taken at the outset of the intervention (Initial test), after 6 weeks (Midway test), at the end of the intervention (Completion test) and approximately 12 weeks later (Follow up test). Main predictions: 1. In the Completion test the primary psychological outcome measure, scores on the Logical Memory test, will be lower in the Sugar group than in the other two groups. 2. In the Completion test the primary metabolic outcome, waist:hip ratio will be larger in the Sugar group than in the other two groups.
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Interventions
Participants are randomly assigned to 3 arms: (1) Sugar group: 4.5L of sugar-sweetened drink per week; (2) Diet group: 4.5L of artificially-sweetened drink per week; (3) Water group: 4.5L of bottled water. Intervention is for 12 weeks. During this period all participants are required to abstain from consuming sweetened drinks other than those given to them. Notes: 1. a) The sugar-sweetened drinks will be commercially available carbonated beverages with sucrose content in the range 9% - 11%. Participants in this arm will be offered a choice between CocaCola, PepsiCola, Sprite and Fanta. Participants in the Diet arm will be offered a choice between the equivalent sugar-free commercial beverages; e.g. Diet Coke, Coke Zero, Diet Pepsi, Sprite Light, which contain artificial sweeteners that can include aspartame, sucralose or stevia, or some combination. b) Participants will be asked to consume no more than 3 of the 375-ml cans per day; otherwise it is up to them to decide when to consume their drink. c) Monitoring of adherence to drinking all 12 cans each week consists of: 1.requiring that participants return the empty cans when they come to collect the next week's supply; and 2. reporting each week what beverages they have consumed in the previous week by completing the Brief 15-item Beverage Questionnaire (BEVQ-15) on each visit to the laboratory. 2. Participants are not asked to change their normal diet other than comply with the instructions on beverages; i.e. there are no further dietary restrictions.
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ACTRN12615001004550