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ActivePhase 4ACTRN12616000033448

Sleep and speech: Objectively monitoring the residual effects of sleep-promoting compounds

Do healthy adults aged 18 - 25 given zolpidem 10mg or temazepam 10mg before bed compared to no treatment show any effect to alertness and executive function, as indicated by speech, upon waking in the middle of the night or waking in the morning.

Sponsor

Monash University

Enrollment

50 participants

Start Date

Jul 18, 2014

Study Type

Interventional

Conditions

Cognitive detriment due to residual effects to the central nervous system after using zolpidem or temazepam.

Summary

To investigate the residual effects of temazepam and zolpidem, and to investigate the analysis of speech for objectively measuring these changes.

Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 25 Yearss

Inclusion Criteria1

  • Healthy adults

Exclusion Criteria15

  • Not having, average, between 7 and 9 hours of sleep.
  • Taking more than 2 naps a week.
  • Currently taking medication affecting the central nervous system.
  • Are recreational drug or alcohol abusers
  • Have 4 or more standard alcoholic drinks in one sitting or more than 2 standard alcoholic drinks per week.
  • Currently smoke.
  • Have a history of neurological trauma
  • Present with poor vocal health
  • Present with a medical condition contraindicative for temazepam and zolpidem
  • Have worked shift work 3 months before the study
  • Have crossed more than two time zones in the last month
  • Use more than 300mg of caffeine a day
  • Suffer from sleep disturbances, disorders
  • Suffer from daytime sleepiness
  • Have used temazepam or zolpidem before.

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Interventions

Over the course of the protocol participants will take a single dose of each drug: A 10mg single dose of zolpidem administered orally via a capsule before bed; A 10mg single dose of temazepam a

Over the course of the protocol participants will take a single dose of each drug: A 10mg single dose of zolpidem administered orally via a capsule before bed; A 10mg single dose of temazepam administered orally via a capsule before bed. There are four groups: Placebo, temazepam and zolpidem are woken during the first slow wave sleep episode after sleep onset. Another placebo group is woken during the first rapid eye movement episode. The wash out period between treatments is 7 days.

Locations(1)

VIC, Australia

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ACTRN12616000033448