Serum lidocaine levels following administration of topical lidocaine during in office laryngopharyngeal procedures
Auckland District Health Board
50 participants
Nov 19, 2018
Observational
Conditions
Summary
In office laryngeal procedures are well tolerated by most patients provided adequate local anaesthesia is achieved. For most laryngologists topical lidocaine is the agent of choice and is considered safe when used in low doses. However the effects of lidocaine toxicity are well known. This study will evaluate and measure the exact serum levels of lidocaine achieved by topical application of lidocaine for in-office procedures in 50 consecutive patients. Analysis will compare real measured levels to reported safe serum levels and correlate this with side effects if present.
Eligibility
Inclusion Criteria3
- Patients undergoing awake laryngopharyngeal procedures in the office requiring topical anaesthesia
- Age >18 years
- Ability to give informed consent
Exclusion Criteria8
- Age <18 yrs
- Preexisting increased risk of bleeding or thrombosis
- Coagulation disorders
- Renal disease
- Hepatic disease
- Pre-exisiting cardiac conduction abnormality
- Inability to provide informed consent
- Allergy to lidocaine
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Interventions
Sampling blood for estimation of lidocaine levels after topical administration of lidocaine during awake laryngopharyngeal procedures (sampled prior to, 5,10,20, 30 and 60 minutes following administration). Currently the reported range of administered lidocaine is from 220mg to 1200mg. At our institution the average administered dose topically is 340mg.
Locations(1)
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ACTRN12616000058471