RecruitingACTRN12616000058471

Serum lidocaine levels following administration of topical lidocaine during in office laryngopharyngeal procedures


Sponsor

Auckland District Health Board

Enrollment

50 participants

Start Date

Nov 19, 2018

Study Type

Observational

Conditions

Summary

In office laryngeal procedures are well tolerated by most patients provided adequate local anaesthesia is achieved. For most laryngologists topical lidocaine is the agent of choice and is considered safe when used in low doses. However the effects of lidocaine toxicity are well known. This study will evaluate and measure the exact serum levels of lidocaine achieved by topical application of lidocaine for in-office procedures in 50 consecutive patients. Analysis will compare real measured levels to reported safe serum levels and correlate this with side effects if present.


Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This study measures the amount of lidocaine (a numbing medicine) that gets into the bloodstream when it is sprayed into the throat and voice box area during in-office procedures. Lidocaine is commonly used to keep patients comfortable during these procedures, but too much in the blood can be dangerous. The study will measure blood levels in 50 patients to confirm the drug is being used safely. You may be eligible if: - You are 18 years of age or older - You are having an awake procedure on your throat or voice box in the clinic - You are able to give informed consent You may NOT be eligible if: - You are under 18 years old - You have a bleeding or clotting disorder - You have kidney or liver disease - You have a heart rhythm problem - You are allergic to lidocaine - You are unable to give consent Talk to your doctor about whether this trial might be right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Sampling blood for estimation of lidocaine levels after topical administration of lidocaine during awake laryngopharyngeal procedures (sampled prior to, 5,10,20, 30 and 60 minutes following administra

Sampling blood for estimation of lidocaine levels after topical administration of lidocaine during awake laryngopharyngeal procedures (sampled prior to, 5,10,20, 30 and 60 minutes following administration). Currently the reported range of administered lidocaine is from 220mg to 1200mg. At our institution the average administered dose topically is 340mg.


Locations(1)

Auckland, New Zealand

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ACTRN12616000058471