Low dose versus standard dose oxytocin in pregnant women undergoing elective caesarean delivery
Effect of 3 units versus 5 units slow intravenous bolus oxytocin on postpartum blood loss in women undergoing elective caesarean delivery
Royal Hobart Hospital
66 participants
Jul 18, 2011
Interventional
Conditions
Summary
This study sought to determine whether 3IU oxytocin was comparable to standard 5IU regarding postpartum blood loss in pregnant women undergoing elective caesarean delivery under spinal anaesthetic, but could reduce blood pressure elevating medication (vasopressor) requirements and adverse events. We hypothesized that patients receiving 3IU oxytocin would be non-inferior to 5IU regarding postpartum blood loss and superior regarding uterine tone, incidence of low blood pressure (hypotension), blood pressure elevating medication (vasopressor) requirements and adverse events.
Eligibility
Inclusion Criteria1
- ASA I –II, term pregnancy (>38 weeks), aged 18 to 40 years and scheduled for elective caesarean delivery.
Exclusion Criteria1
- Clinical history of hypertensive disorders (pre eclampsia; chronic hypertension), haemodynamic instability (systolic blood pressure < 100 mmHg), bleeding diastasis (thrombocytopenia, coagulopathies) and history of uterine atony causing post-partum haemorrhage.
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Interventions
Slow bolus intravenous injection of 3 units oxytocin administered by anaesthetist over 60 seconds at the time of delivery.
Locations(1)
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ACTRN12616000398404