The efficacy of intravenous ibuprofen and pregabalin before posterior lumbar stabilisation surgery on postoperative pain.

For managing acute postoperative pain, new medical treatments administered preoperatively. For this purpose, pregabalin has been used previously for lumbar fusion surgery in some clinical research. Intravenous ibuprofen ( NSAID analgesic) used until 2009. We want to investigate the effect of pregabalin+intravenous ibuprofen used before the operation preemptively on postoperative analgesia for lumbar fusion surgery. We enroll 42 patients who undergone elective lumbar fusion surgery. Exclusion criteria; antiepileptic drug use, allergic reaction for study drugs, ASA III-IV patients. mild or severe renal insufficiency. Group Pregabalin: 1 hour before operation patients will take 150 mg pregabalin oral form. Group Pregabalin + intravenous ibuprofen: 1 hour before operation patients will take 150 mg pregabalin oral form. Additionally 1/2 hour before operation patients will take 800 mg intravenous ibuprofen. After operation we give patient controlled analgesia contains morphine, and we will evaluate postoperative pain.