RecruitingACTRN12616001095459

Evaluating response to exercise programs in monozygotic and dizygotic twins to determine whether exercise response is generic, genetic or modality dependent.

Towards Exercise as Personalised Medicine: Is Non-Response to Exercise Generic, Genetic or Modality Dependent?

Sponsor

Winthrop Professor Daniel Green

Enrollment

100 participants

Start Date

Jan 10, 2017

Study Type

Interventional

Conditions

Cardiovascular health responses to exercise modalities in apparently healthy subjects

Summary

There has never been a more sedentary population than the 21st century western society, with physical inactivity accounting for a similar number of deaths per annum as tobacco. Physical inactivity is a modifiable risk factor for chronic disease, especially cardiovascular diseases, and no other intervention possesses the broad spectrum of health impacts that can be attributed to exercise. However, the cardiovascular response of an individual to exercise is idiosyncratic and, whilst most individuals incur favourable effects, a sizeable proportion (~30%) of individuals either do not respond or respond “adversely” to exercise. The current research study aims to answer two fundamental questions. Firstly, is non-response to one exercise modality universal across all modalities? Secondly, to what extent is non-response to exercise environmentally versus genetically determined?

Eligibility

Sex: Both males and femalesMin Age: 15 YearssMax Age: 40 Yearss

Plain Language Summary

Simplified for easier understanding

This study is for healthy twin pairs who want to help researchers understand why some people respond well to exercise and others do not. The study compares identical twins (who share all their genes) with non-identical twins (who share about half their genes) to figure out whether a person's response to exercise is determined more by their genes or their lifestyle. You may be eligible if: - You are between 15 and 40 years old - You are part of a twin pair (either identical or non-identical) - You exercise less than 150 minutes per week at moderate intensity - You are in general good health You may NOT be eligible if: - You drink more than 4 units of alcohol per day - You have a serious health condition (e.g., cancer, heart disease, diabetes, stroke) - Your BMI is over 35 - You have had a heart attack or have heart failure - You take medications that affect heart function - You already exercise more than 150 minutes per week Talk to your doctor about whether this trial might be right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Print for Your Doctor Check Your Eligibility

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

Twin pairs will be randomised to simultaneously undertake 36 sessions of 3 sessions per week of either resistance or endurance training. This will be followed by a 12 week washout period. Each twin pair will then cross-over to start a similar period of training with the alternate intervention. Each exercise session will last for 1 hr and be group, centre-based and supervised by and exercise scientist at the UWA Sport Science research gym. Adherance will be monitored by registering attendance at each session. The resistance training will consist of weighted exercises at an intensity according to RPE (>14/20) and endurance training will consist of running and cycle ergometer at intensity according to HR max (60%+).

Locations(1)

WA, Australia

View Full Details on ANZCTR

For the most up-to-date information, visit the official listing.

Visit

ACTRN12616001095459