RecruitingACTRN12616001130459

Monitoring exposure of Western Victorian farmers to organophosphate pesticides

In-field Personalised Cholinesterase Assessment Project (In-field PCAP): Monitoring Victorian farmers exposed to agricultural pesticides in workplace

Sponsor

Deakin University

Enrollment

50 participants

Start Date

Apr 4, 2016

Study Type

Observational

Conditions

Insulin resistance (Fasting blood sugar)Organophosphate exposure

Summary

Aims: This study aims to develop the methodology for clinical point of care (POC) sampling to determine the level of exposure to organophosphates (OP’s) by western Victorian farmers. Significance: This methodology will test for cholinesterase activity and provide the basis for future research work by identifying the potential chemical exposure pathways of individuals most at risk in farming communities. Expected outcomes: The study will provide a methodology for cholinesterase activity measurement in farmers and the possible integration of POC sampling in farmer health checks. Importantly it will highlight pesticide contact as a risk for farmers, leading to further research to quantify pesticide exposure both on the farm and in the home of farming families.

Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 75 Yearss

Plain Language Summary

Simplified for easier understanding

This study is for farmers and farm workers in south-west Victoria who regularly work with pesticides — particularly organophosphate-based chemicals commonly used in agriculture. These chemicals can affect the nervous system. The study tests blood enzyme levels (cholinesterase activity) to measure how much exposure farmers are getting, to better understand their health risks and improve future monitoring. You may be eligible if: - You are between 18 and 75 years old - You are a farmer or farm worker who regularly works with organophosphate pesticides - You have not had a known serious chemical exposure incident - You live in south-west Victoria - You do not have a known chronic disease - You are not taking anti-inflammatory drugs or supplements You may NOT be eligible if: - You are under 18 years old - You have recently had a known serious chemical incident - You have a known chronic disease - You take anti-inflammatory drugs or supplements Talk to your doctor about whether this trial might be right for you.

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Interventions

Target Population: Western Victorian farmers and agricultural workers engaged in crop and livestock operations, with self-reported use of agrichemicals and cholinesterase inhibiting insecticides. B

Target Population: Western Victorian farmers and agricultural workers engaged in crop and livestock operations, with self-reported use of agrichemicals and cholinesterase inhibiting insecticides. By measuring the activity of the enzyme cholinesterase, exposure to organophophates can be identified. Enzyme activity will be monitored every 4 weeks over the 12 months period. Each participant will receive a baseline health check during the first visit including: a) Measurements: Height, weight, waist and hip circumference, body fat percentage, blood pressure, pulse rate. b) Capillary blood sample : Collected using a finger prick, will test for : Fasting blood glucose, establish personal quantitative estimates of both red blood cell ChE and Plasma ChE. c) Health and Chemical usage survey: Complete chemical use and well being questionnaire For the subsequent visits, each participant will undergo: a) Capillary blood sample: Individualised cholinesterase activity level measured , recorded and discussed by registered nurse. b) Health and Chemical usage survey: Chemical use and well being questionnaire

Locations(3)

Western District Health Service - Hamilton - Hamilton

VIC, Australia

Western District Health Service - Coleraine - Coleraine

VIC, Australia

Western District Health Service - Penshurst - Penshurst

VIC, Australia

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ACTRN12616001130459