A Comparative Study of Clonidine and Magnesium sulfate Premedication on peri operative hormonal stress responses, hemodynamic stability and postoperative analgesia in Laparoscopic Cholecystectomy
A comparative study of clonidine and magnesium sulfate premedication on peri operative hormonal stress responses, hemodynamic stability and postoperative analgesia in patients with gallbladder diseases undergoing laparoscopic cholecystectomy: A randomized, double-blind, controlled study
South valley university
105 participants
Jan 10, 2016
Interventional
Conditions
Summary
We will compare preoperative administration of I.V. clonidine and magnesium sulphate in laparoscopic cholecystectomy on stress hormones( cortisol and ACTH levels) , hemdynamic stability and post operative analgesia.
Eligibility
Inclusion Criteria1
- American society of A nesthesiologists( ASA) I and II, patients with gallbladder diseases subjected for elective laparoscopic cholecystectomy( LC) .
Exclusion Criteria1
- Patients with cardiovascular,respiratory,renal, hepatic or neurological diseases, diabetes mellitus, pregnancy or breast feeding females, morbidly obese patients, endocrine disorders,prolonged procedures ( more than 120 minutes), patients on anti hypertensives, antipsychotics, analgesics or sedative medications
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Interventions
3 groups are included in which a total volume of 50 ml . Isotonic saline (0.9%) are given slow intravenous (I.v) infusion over 15 minutes before induction of general anesthesia Group 1: received 1.5 ug/kg of clonidine in the infusion regimen Group 2: received 30 mg/kg of Magnesium sulfate in the infusion Group 3: received saline only(placebo group) infusion of 50 ml. saline
Locations(1)
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ACTRN12616001233415