A Comparative Study of Clonidine and Magnesium sulfate Premedication on peri operative hormonal stress responses, hemodynamic stability and postoperative analgesia in Laparoscopic Cholecystectomy

This study is comparing two medications — clonidine and magnesium sulphate — given before gallbladder removal surgery (laparoscopic cholecystectomy) to see which better reduces stress hormones, keeps blood pressure stable during the operation, and provides better pain relief afterward. You may be eligible if: - You are between 18 and 60 years old - You have a gallbladder condition and are scheduled for elective laparoscopic cholecystectomy - You are classified as low to moderate surgical risk (ASA I or II) You may NOT be eligible if: - You have heart, lung, kidney, liver, or neurological disease - You have diabetes, are pregnant, or are breastfeeding - You are severely obese - You have an endocrine disorder - You take blood pressure, antipsychotic, pain, or sedative medications - Your surgery is expected to take longer than 2 hours Talk to your doctor about whether this trial might be right for you.