An ex vivo investigation into diagnosis of coeliac disease by multiple light-based methods. A proof of principle study towards future development of an in vivo point of care diagnosis device.

This study is testing whether light-based techniques — such as Raman, infrared, and fluorescence spectroscopy — can detect coeliac disease in tissue samples taken during a routine gastroscopy. Coeliac disease is a condition where eating gluten damages the lining of the small intestine. Currently, diagnosis requires a biopsy and lab testing. This research aims to develop a faster, point-of-care tool that could be used during the procedure itself. You may be eligible if: - You are 16 years of age or older - You are already scheduled for a gastroscopy (stomach scope) for any reason - You are willing to have 2 to 4 additional small tissue samples (biopsies) taken during the procedure You may NOT be eligible if: - You are under 16 years of age - You have a bleeding disorder - You are taking blood-thinning (anticoagulant) medications - You have a severely weakened immune system Talk to your doctor about whether this trial might be right for you.