Effect of Sublingual (under the tongue) Rosuvastatin/Crestor (cholesterol/statin medication) in reducing the side effects experienced in subjects with high cholesterol & a history of cardiovascular disease (heart attack, coronary artery disease) with a known statin intolerance.

This study is testing whether taking a cholesterol-lowering statin (rosuvastatin) under the tongue — instead of swallowing it — reduces the muscle aches, memory problems, and other side effects that caused the person to stop taking statins in the first place. People who need statins for heart disease but can't tolerate them may benefit from this alternative way of taking the medication. You may be eligible if: - You are 18 years of age or older - You have had side effects from statins such as muscle pain or memory changes - You stopped taking statins more than 1 month ago - You have a history of heart disease or coronary artery disease - Your total cholesterol is above 5.5 mmol/L and has not reached the target level You may NOT be eligible if: - You have uncontrolled diabetes (HbA1c above 9%) - You have abnormal liver enzymes or elevated creatine kinase - You have significant kidney impairment - You have a history of drug or alcohol dependency - You are a woman using hormonal therapy or oral contraceptives - You are pregnant or breastfeeding Talk to your doctor about whether this trial might be right for you.