RecruitingPhase 4ACTRN12616001713482

Randomised placebo controlled trial of inhaled corticosteroids for treatment of chronic cough in children.

Is a two week course of inhaled corticosteroids efficacious for reducing cough severity in children with chronic cough, compared to placebo?


Sponsor

Prof Anne Chang

Enrollment

77 participants

Start Date

Jun 7, 2011

Study Type

Interventional

Conditions

Summary

This study will help us answer the question: should children with chronic cough be given inhaled corticosteroids to promote faster recovery and improve ability for children to return to their normal daily routines? This study will also evaluate whether fractional exhaled nitric oxide levels can predict short term response to inhaled corticosteroids in children with chronic cough. We hypothesise that a short (two week) course of inhaled corticosteroids will reduce cough severity in children with chronic cough, and that FeNO measurements can be used to predict this response.


Eligibility

Sex: Both males and femalesMin Age: 18 MonthssMax Age: 16 Yearss

Plain Language Summary

Simplified for easier understanding

This study is testing whether a 2-week course of inhaled corticosteroids (steroid puffers) can speed up recovery from chronic cough in children. Chronic cough is defined as a cough lasting 4 weeks or more. Researchers are also testing whether a specific breathing test (FeNO — measuring nitric oxide in exhaled breath) can predict which children will respond best to this treatment. You may be eligible if: - Your child has a cough lasting 4 weeks or more - Your child is between 18 months and 16 years old - Your child is able to use an inhaler with a spacer device You may NOT be eligible if: - Your child received oral or inhaled steroids in the week before this study - Your child is unable to tolerate inhaled corticosteroids or use a spacer - Your child has cerebral palsy or a severe developmental disability - Your child has a confirmed chronic respiratory illness (e.g., asthma already diagnosed) - Your child has a weakened immune system Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Children will be randomised to receive either inhaled corticosteroids or placebo. Children allocated to the intervention group will receive 250 micrograms fluticasone propionate twice daily for two we

Children will be randomised to receive either inhaled corticosteroids or placebo. Children allocated to the intervention group will receive 250 micrograms fluticasone propionate twice daily for two weeks, delivered via metered dose inhaler and spacer (with or without mask, depending on age and technique).


Locations(2)

Lady Cilento Children's Hospital - South Brisbane

NT,QLD, Australia

Royal Darwin Hospital - Tiwi

NT,QLD, Australia

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ACTRN12616001713482