The effects of exercise on vaccination responses - the role of timing and site of active muscle
The effects of exercise on vaccination responses in healthy young adults - the role of timing and site of active muscle
The University of sydney
80 participants
Apr 24, 2017
Interventional
Conditions
Summary
This study investigates the effect of exercising different limbs (arm vs. leg), and timing (pre- vs. post-) on responses to vaccination. A single bout of exercise has been shown to improve vaccination responses, the proposed mechanisms include increased blood and lymph flow of the exercising muscle. This suggests that arm exercise would have stronger effects than leg exercise (if a vaccine is given in the arm). All studies of exercise effects on vaccinations have used exercise pre-vaccination. But post-vaccination exercise might be more effective as the antigen can benefits from increased blood and lymph flow and increased immune cell numbers.
Eligibility
Inclusion Criteria1
- Eligible adults between the ages of 18 - 30 years, have passed the PAR-Q, and who have not previously received the influenza vaccine in 2016, and have no contraindications to vaccination.
Exclusion Criteria1
- Contraindication to vaccination as listed in the most current Immunisation Handbook, including anyone who has experienced an anaphylactic reaction to any component of the vaccine (including yeast) or following a previous dose of vaccine; history of vaccine related allergies or side-effects; current immune disorder (e.g. glandular fever) or acute infection; pregnant or suspected pregnancy; current medication (e.g., prescription medication, anti-inflammatories); egg allergies; unable to participate in exercise activity screened by PAR-Q.
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Interventions
Participants will be randomised (by computer randomisation table) into one of four groups: Control (Con), Pre-Vaccination Leg Exercise (PreLeg), Pre-Vaccination Arm Exercise (PreArm) or Post-Vaccination Arm Exercise (PostArm). The PreArm and PreLeg groups will perform the exercise task and immediately after completion will receive the vaccination. The Con and PostArm groups will receive the vaccination according to standard procedure after a 15-minute resting period. The PostArm group will perform the exercise task immediately after receiving the vaccine while all other groups will rest quietly. The exercise session will be supervised by an experienced trainer. Exercise tasks: All the participants except for the participants allocated to the Con group will take part in 15- minute exercise. The participant’s allocated to PreArm and PostArm group will partake in a task involving 30 seconds of exercise followed by 30 seconds rest, alternating between 3 upper body exercises (biceps curls, lateral raise, and chest press) using an exercise band. This task has previously been used safely in a study involving young healthy adults, and was shown to increase the immune response to the Pneumococcal vaccine. The task requires minimal, inexpensive equipment, no specialised environment, is easily transportable and implementable and requires no prior exercise experience. The participant allocated to PreLeg group will also partake in a task involving 30 seconds of exercise followed by 30 seconds rest, alternating between 3 lower body exercises (squats, lunges and calf raises). We will be using Fluquadri Adult, an influenza vaccine of 0.25 mL dose administered intramuscular into the deltoid.
Locations(1)
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ACTRN12617000374369