Effect of sugar and blackcurrant consumption on the health properties in healthy adults
Effect of sugar and blackcurrant consumption on the bioavailability profile of blackcurrant-derived polypenols and antioxidant capacity in healthy adults.
Jocelyn Eason
45 participants
May 1, 2017
Interventional
Conditions
Summary
Scientific evidence suggests that sugar can enhance the digestion and absorption of berry-derived antioxidant compounds presenting an opportunity for the development of berry foods with enhanced antioxidant properties. In particular, blackcurrant consumption is shown to maintain antioxidant capacity and support recovery from oxidative stress. We have gathered proprietary information on the composition and bioavailability of NZ blackcurrant fruits and derived products, and now turn our focus to how to enhance the bioavailability of blackcurrant-derived polyphenolic compounds to support health. In this pilot study we aim to explore the effect of sugar on the bioavailability of blackcurrant-derived phenolic compounds to formulate nutritional intervention strategies to maximize antioxidant properties.
Eligibility
Inclusion Criteria1
- Healthy individuals (male or female) aged 16-60 years old. Individuals will be required to complete a health questionnaire and provide informed written consent.
Exclusion Criteria1
- Individuals will be excluded if they are unwilling or unable to provide informed written consent or comply with the study procedures. Participants will also be excluded if they have (i) known hypersensitivity or intolerance to blackcurrants or berry fruit-derived products, (ii) health conditions that may affect their ability to regulate sugar digestion/absorption (i.e. diabetes, metabolic syndrome). In addition, participants will be excluded if they are pregnant or planning to get pregnant in the near future or have any of the following conditions: (i) blood borne diseases (e.g. hepatitis), (ii) clinically diagnosed high/low blood pressure, (iii) recent bacterial or vial illness, (iv) are taking any mediation that affects the properties of blood (e.g. blood clotting). Furthermore, potential volunteers will be excluded if they have donated blood within 4 weeks from the start of the study.
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Interventions
This trial is aimed at assessing how sugar consumption influences blackcurrant metabolism and antioxidant properties. The trial is a parallel design. This design was selected since the influence of sugar consumption of the time-dependent bioactivity of blackcurrant-derived polyphenolic compounds within the body is currently unknown; a parallel trial design will eliminate any potential problems from a cross-over design. Participants will be randomised into 3 trial arms; arm 1 will consume a 200 mL blackcurrant drink containing a whole blackcurrant extract equivalent to 3.2 mg polyphenolic compounds /Kg diluted in water, arm 2 will consume a blackcurrant drink (containing the same amount of blackcurrant extract described for arm 1) containing 40 g sucrose and arm 3 will consume a blackcurrant drink (containing the same blackcurrant extract described for arm 1) and then 1 hr later will consume a 200 ml sugar drink containing 40 g sucrose. The blackcurrant extract and sucrose was commercially sourced from Sujon Berries (New Zealand) and Healtheries (New Zealand) and dinks were prepared under New Zealand food safety requirements. The trial will take place in designated clinical facilitates within PFR and will be conducted by experience trial co-ordinators, who are also First Aider and trained phlebotomist. The trial co-ordinator will monitor the welfare of participants and ensure that they adhere to trial arm protocols. Participants will be randomised into one of the trial three arms. In all three trial arms a venous blood sample (~ 15 mL) will be taken prior to the consumption blackcurrant +/- sugar drinks, in trial arms 1 and 2, after the consumption of the drinks, blood samples will be collected at 1, 2, 3 and 4 hrs post consumption. In trial 3, blood samples will be taken after both the consumption of the blackcurrant drink and then 1 hr later after the consumption of the sugar drink. In addition, further blood samples will be taken at 2, 3 and 4 hr after the consumption of the initial blackcurrant drink.
Locations(1)
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ACTRN12617000732381