Single dose study of febuxostat (80 mg) in healthy subjects.
The pharmacokinetics and pharmacodynamics of a single dose of febuxostat (80 mg) in healthy subjects.
St Vincent's Hospital, Sydney
10 participants
Jul 5, 2016
Interventional
Conditions
Summary
Healthy subjects will be administered a single dose of febuxostat (80 mg) to examine the the pharmacokinetic and pharmacodynamic profiles of febuxostat following the administration of a single dose (80 mg). This study will also investigate the effect of a single dose of febuxostat (80 mg) on the renal handling of urate.
Eligibility
Plain Language Summary
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Interventions
Healthy subjects will be orally administered a single dose of febuxostat (80 mg). Urine (total catch) and blood samples will be collected at baseline (before administrating the dose) and for 102 hours post dose administration. No adherence assessment is required in this single dose study.
Locations(1)
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ACTRN12617001346369